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Anti-progestational action of norethindrone-oxime in rabbits

   
@article{APS5007,
	author = {Xiao-ling GAO and Dun-zhou LI},
	title = {Anti-progestational action of norethindrone-oxime in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Relative binding affinities (RBA) of norethindrone-oxime (NETO) and norethindrone (NET) measured by dextrancoated charcoal adsorption were in the following order: NET>progesterone>NETO. Both NETO and NET exhibited a competitive inhibition with the binding of progesterone on its receptor-like sites. In addition, NETO possessed a significant anti-progestational action, while NET did not show an effect even at a dose as high as 16 mg. These results indicated that NETO antagonized progesterone at receptor level and it was assumed that oximation of NET at C3 increased its antiprogestational activity.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5007}
}