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Effects of henbane drugs on electrophysiological and mechanical properties of guinea pig papillary muscle

   
@article{APS4982,
	author = {Dong-Xu Ren and Jun Ke and Shi-Ai Weng},
	title = {Effects of henbane drugs on electrophysiological and mechanical properties of guinea pig papillary muscle},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {The henbane drugs (HD) had similar effects on fast action potentials (AP) and contractile force (FC) of guinea pig papillary muscle. Either atropine (Atr) 50μmol/L or scopolamine (Sco) 0.3 mmol/L or anisodamine (Ani) 0.3 mmol/L could increase ERP/APD ratio, prolong CT and suppress FC. The spontaneous rhythms were almost abolished after treatment with Atr 10μmol/L，Sco 0.l mmol/L or Ani 0.l mmol/L, respectively. Slow AP was induced by isoprenaline or histamine (1μmol/L) after cardiac cells were depolarized in K+-rich (22 mmol/L) solution. Either Atr 0.1 mmol/L or Sco 0.6 mmol/L or Ani 0.6 mmol/L had partial inhibitory effect on both kinds of slow AP. The results suggest that comparative high concentration of HD possess antiarrhythmic effect and unspecific calcium channel-blocking effect.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4982}
}