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Effect of praziquantel on mice immunity in early stage after infection with Schistosoma japonicum cercariae1

   
@article{APS4955,
	author = {Shu-Hua Xiao and Gong-Ze Wu and Hai-Chou Xue and Hui-Fang Guo and Guang-Cheng Song and Li-Shu Qiu},
	title = {Effect of praziquantel on mice immunity in early stage after infection with Schistosoma japonicum cercariae1},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {When BABI/C mice, infected with about 300 Schistosoma japonicum cercariae for 3 h, were given intragastrically with praziquantel at a single dose of 400 mg/kg, the phagocytosis of their peritoneal macrophages increased significantly within 2-72 h after the medication. The proliferative response of splenic lymphocytes induced by PHA and Con A increased at 72 h after the treatment. This increase in stimulation index of lymphocytes to PHA and Con A occurred also in uninfected BABL/C mice treated with the same dose of praziquantel. No effect of praziquantel on total serum complement content of BABL/C mice was observed.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4955}
}