How to cite item

Effects of 1-nitropyrene pretreatment on the mixed-function oxidases of rat liver

   
@article{APS4953,
	author = {Shao-Xiong He and Francis C P Law},
	title = {Effects of 1-nitropyrene pretreatment on the mixed-function oxidases of rat liver},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The inducibility of hepatic mixed-function oxidases (MFO) was examined in adult rats following ip or dermal applications of l-nitropyrene (l-NP) at a daily dose of 30 mg/kg for 3d. The liver weights, hepatic microsomal cytochrome p-450 and b5 contents, and 7-ethoxycoumarin O-deethylase and benzopyrene hydroxylase activities of rats treated with l-NP ip were induced significantly. In contrast, hepatic aminopyrine N-demethylase activity was unaffected. Pretreatment of rats with l-NP applied on the skin did not alter significantly the liver weights and hepatic MFO activities. These results indicate that 1-NP is a 3-methyIcholanthrene-type inducer of hepatic MFO but it is not absorbed by the skin of adult rats.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4953}
}