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Effects of hyoscine-N-butyl bromide on electroencephalography and neuromuscular junction

   
@article{APS4947,
	author = {Shi-Min Lu and Xian-Yu Chen},
	title = {Effects of hyoscine-N-butyl bromide on electroencephalography and neuromuscular junction},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {After iv hyoscine-N-butyl bromide (HNB) 20 mg/kg, the rabbits became restless without convulsion, and the EEG showed discrete sharp waves and spikes, without epileptic discharges. It suggested that iv HNB possesses some stimulating effect on CNS.
  Epileptic discharges of EEG and repeated clonic convulsion induced by icv HNB 3 mg were antagonized by diazepam, but not by physostigmine. It suggested that the effect of HNB be related to the GABAnergic, not cholinergic, modulating function.
  HNB (0.1-2 mmol/L) produced a concentration-dependent blocking the neuromuscular junction on rat phrenic nerve-diaphragm preparation. This result indicates that iv HNB inhibits respiration probably via the blocking of neuromuscular junction.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4947}
}