@article{APS4921,
author = {De-lu Zhao and Shu-qiu Pei and Chuan-gui Liu},
title = {Effects of intravenous injection of soman on specific binding with 3H.QNB in rat brain homogenates},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {4},
year = {2016},
keywords = {},
abstract = {Rats were injected iv soman 25-70 microg and , after 15 min, the specific binding of [3H]QNB to their whole brains (except cerebellum) homogenates was studied by radioligandreceptor assay. Soman inhibited the [3H]QNB binding in a dose-depependent manner and the ID50 was 66 microg/kg. But the inhibition was diminished when the iv dose of soman was over 70 microg/kg. Double-reciprocal plot of data revealed that the inhibition of soman on [3H]QNB binding was competitive. This inhibition took place before complete inhibition of cholinesterases(ChE)by soman. The dual actions of soman on ChE and M-AChR in vivo confirmed our previous results in vitro.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4921}
}