%0 Journal Article %T Toxicity of medium chain triglycerides and its influence on serum cholesterol %A SHI Jue-min %A CHEN Xue-xin %A ZHANG Wen-juan %A ZHOU Ming-hua %A YANG Jia-luo %A YIN Yao-cheng %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Toxicity of medium chain triglycerides and its influence on serum cholesterol %K %X Medium chain triglycerides (MCT), a kind of neutral fats extracted from camphor tree drupes and composed mainly of C10 saturated fatty acid triglycerides, were hydrolyzed and absorbed rapidly. When dogs were fed MCT 2 or 5 ml/kg/d for 102 d there were no remarkable changes in ECG, hematological and histological examinations, as well as hepatic and renal function tests. The blood content of MCFA reached the peak at 1.5 h after feeding and then declined in 4 h. MCT reduced serum and liver cholesterol levels in rabbits, rats, and dogs. MCT is very stable and can safely be used as medicine and nutriment. %U http://www.chinaphar.com/article/view/4905 %V 7 %N 2 %P 145-148 %@ 1745-7254