@article{APS4875,
author = {Hong-bo Weng and Qian Gu and Meng Liu and Neng-neng Cheng and Duan Li and Xin Gao},
title = {Increased secretion and expression of amylin in spontaneously diabetic Goto-Kakizaki rats treated with rhGLP-1 (7–36)},
journal = {Acta Pharmacologica Sinica},
volume = {29},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the effect of recombined human glucagon-like peptide 1 (rhGLP-1 [7–36]) on the secretion and expression of amylin in Goto-Kakizaki (GK) rats.
Methods: The GK rats were treated with rhGLP-1 (7–36) 56 and 133 μg·kg−1 subcutaneously for 12 weeks. The fasting and post-prandial blood glucose levels were measured. The plasma amylin concentration was measured by ELISA. The transcription levels of amylin and insulin mRNA were evaluated by fluorescent-quantitative-PCR. Immunohistochemistry was utilized to detect the amylin protein. Histological examination was assayed by light microscopy.
Results: Treatment with rhGLP-1 (7–36) caused a significant reduction of post-prandial blood glucose levels in the GK rats (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4875}
}