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Effects of anemodeanin A on DNA, RNA and protein of tumor cells in vitro and plasma cAMP in mice

  
@article{APS4846,
	author = {Li-sheng Liu and Xian-hua Xiao and Long-di Zhang and Rong-liang Zheng and Feng-e Wu and Zi-qin Zhu},
	title = {Effects of anemodeanin A on DNA, RNA and protein of tumor cells in vitro and plasma cAMP in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Oleanolic acid 3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl-(1-2)-alpha-L-arabinopyranoside(anemodeanin A) was extracted from Anemone raddeana Regel. Anemodeanin A 30 microg/mL obviously inhibited DNA, RNA and protein syntheses of sarcoma 180 and ascetic hepatoma cells during the period of 12-48 h after exposure in vitro. ID50 of anemodeanin A on DNA synthesis in ascetic hepatoma cells at 48 h was 21 microg/mL. This drug ip 10 mg/kg* 5 d elevated the plasma cAMP of mice by 61%.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4846}
}