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Analysis of anti-arrhythmic activity of cimetidine in anesthetized guinea pigs

   
@article{APS4820,
	author = {Shao-xuan FU and Yun-shan LI},
	title = {Analysis of anti-arrhythmic activity of cimetidine in anesthetized guinea pigs},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {In anesthetized guinea pigs, iv cimetidine (CMT) 1.12, 2.25, 4.5 mg/kg/min and iv diphenhydramine (DPH) 170 microg/kg/min increased the dose of aconitine required to induce arrhythmia and death; Iv histamine 20 microg/kg/min enhanced the arrhythmic action of aconitine and abolished the anti-arrhythmic effect of CMT, but failed to influence that of DPH. The results indicate that the action of CMT on aconitine-induced arrhythmia in guinea pigs may be mediated via cardiac H2 receptors, whereas that of DPH may be resulted from its membrane-stablizing effects.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4820}
}