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Effect of 3,4-dihydroxyacetophenone on generation of PGI2-like substances in rat aorta

   
@article{APS4815,
	author = {Zhong WANG and Hai-quan GAO and Guo-qiang ZHU and Yan AN and Ru-song HUANG},
	title = {Effect of 3,4-dihydroxyacetophenone on generation of PGI2-like substances in rat aorta},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Studied against platelet aggregation, 3, 4-dihydroxyacetophenone (DHAP) 200 microg/mL decreased the formation of PGI2-like substances by rat aorta rings in vitro. However 1 microg/mL which inhibited AA-induced aggregation 90% or 60 mg/kg administered in vivo did not inhibit the generation of PGI2. On the contrary, indomethacin inhibited PGI2 generation significantly either in vitro or in vivo. 
There is a synergic effect of DHAP and the fluid incubating rat aorta rings on inhibition of platelet aggregation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4815}
}