How to cite item

Effects of silybin on hemodynamics in anesthetized open-chest cats

   
@article{APS4814,
	author = {Yao-cheng RUI and Xin-sheng CHEN and Ai-hua GUAN and Ju-shan HAN},
	title = {Effects of silybin on hemodynamics in anesthetized open-chest cats},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Silybin 22, 44, 88 mg/kg iv lowered the amplitude and duration of diastolic blood pressure (DBP) more than those of systolic (SBP). That the descending aortic blood flow (DABF) did not change significantly suggests a reduction of peripheral resistance and dilatatory action on the resistant blood vessels. Silybin 88 mg/kg iv produced a marked depression of cardiac contractility: decreased left ventricular systolic pressure (LVSP), maximal rate of change of intraventricular pressure (dp/dtmax) and VCE at common peak isovolumetric intraventricular pressure (VCE-CPIP). This drug caused no marked alteration in ECG and heart rate. Toxic dose of silybin caused an elevation of T wave and a depression of A-V conduction.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4814}
}