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Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry

   
@article{APS4812,
	author = {Xiao-fen Li and Yi-ping Wang},
	title = {Depside salts from  Salvia miltiorrhiza  improve myocardial microperfusion in rats using laser Doppler flowmetry},
	journal = {Acta Pharmacologica Sinica},
	volume = {28},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myocardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats.
Methods: Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system.
Results: Intravenous administration of S miltiorrhiza depside salts resulted in a significant immediate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4812}
}