@article{APS4806,
author = {Bao-ruo Shao and Xiu-yu Ye and Hao Zheng},
title = {Stability of drug resistance of a pyronaridine-resistant line of Plasmodium berghei},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {3},
year = {2016},
keywords = {},
abstract = {Pyronaridine-resistant line (RP line, passage 35, resistance>299 fold) of Plasmodium berghei was successively passed through mice under drug pressure of 600 mg(base)/kg of pyronaridine.When the drug pressure was lifted for 5 passages from Passage 49, the parasites completely lost their resistance to pyronaridine. The drug resistance of RP line dropped slightly when the parasites of Passage 115 were subjected to 21-51 serial passages in the absence of drug pressure. Pyronaridine-resistance was stable in Passage 134, as nodecrease of resistance was detected in the parasites following 31 passages without drug pressure.The parasites under drug pressure for a long period retained not only the high resistance to pyronaridine but also cross resistance to chloroquine.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4806}
}