%0 Journal Article %T Comparison of the mutagenicity of 4 nitrofurans in a Salmonella/microsome system %A Ni Yi-chang %A Xu Yue-qin %A Shao Bao-ruo %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Comparison of the mutagenicity of 4 nitrofurans in a Salmonella/microsome system %K %X Mutagenicity of 4 nitrofurans were determined at various concentrations in 4 histidine-requiring strains of Salmonella typhimurium, with or without liver microsomal metabolic activation. The concentration-effect curves of mutagenicity of 4 nitrofurans were also tested in the sensitive strain, TA 100. The proper order of mutagenicity of 4 nitrofurans tested is furazolidone>M-254>furapyrimidone>nitrofurantoin, by comparisons of both the positive dose ranges in TA 100 and TA 98 and the concentration-effect curves in TA 100. %U http://www.chinaphar.com/article/view/4780 %V 6 %N 2 %P 134-137 %@ 1745-7254