TY - JOUR AU - HU Wen-shu AU - ZHOU Zheng-hang AU - HU Chong-jia AU - LV Fu-hua PY - 2016 TI - Effects of tetrandrine on seven vascular smooth muscles JF - Acta Pharmacologica Sinica; Vol 5, No 4 (December 1984): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The effects of tetrandrine (Tet) on seven isolated vascular strips of rabbit were compared. The influence of Tet, verapamil (Ver) and phentolamine (Phen) on noradrenaline (NA) dose-response curves were studied. Tet injibited the contraction evoked by high K+ (60 mM) in thoracic aortic strips and more prominently in mesenteric arterial strips. Phen competiticely antagonized NA. Tet and Ver also antagonized NA but in a noneompetitive manner. Calcium was antagonized by Tet and Ver noncompetitively. The findings suggest that the Tet-induced telaxation on vascular smooth muscle results from its antagonism to calcium, similar to verapamil. UR - http://www.chinaphar.com/article/view/4766