@article{APS4766,
author = {Wen-shu HU and Zheng-hang ZHOU and Chong-jia HU and Fu-hua LV},
title = {Effects of tetrandrine on seven vascular smooth muscles},
journal = {Acta Pharmacologica Sinica},
volume = {5},
number = {4},
year = {2016},
keywords = {},
abstract = {The effects of tetrandrine (Tet) on seven isolated vascular strips of rabbit were compared. The influence of Tet, verapamil (Ver) and phentolamine (Phen) on noradrenaline (NA) dose-response curves were studied. Tet injibited the contraction evoked by high K+ (60 mM) in thoracic aortic strips and more prominently in mesenteric arterial strips. Phen competiticely antagonized NA. Tet and Ver also antagonized NA but in a noneompetitive manner. Calcium was antagonized by Tet and Ver noncompetitively.
The findings suggest that the Tet-induced telaxation on vascular smooth muscle results from its antagonism to calcium, similar to verapamil.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4766}
}