How to cite item

Central and cardiac histamine receptors involvement in the anti-arrhythmic effect of cimetidine

   
@article{APS4763,
	author = {Yun-shan LI and Shao-xuan FU},
	title = {Central and cardiac histamine receptors involvement in the anti-arrhythmic effect of cimetidine},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Intracerebroventricular injection (icv) of cimetidine 37.5μg delayed and icv histamine diphosphate 20 μg shortened the onset o fbentricular extrasystole (VE) and ventricular tachycardia (VT) produced by icv aconitine 15 μg/μl in the anesthetized rats,whereas icv diphenhydramine 37.5μg exerted no influence on these arrhythmias.
In the spinal rats, cimetidine 120 mg/kg iv significantly elevated the dose of aconitine (2 μg/min iv) required to induce VE, VT and ventricular fibrillation(VF), but iv infusion of histamine diphosphate (20 mg/kg/h) did not. Therefore these results suggested that cimetidine antagonized aconitine-arrhythmia through the central H2-receptors and peripheral mechanism was independent of the cardiac histamine receptor.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4763}
}