@article{APS4755,
author = {Wei-xin SHI and Yan CHEN and Guo-zhang JIN},
title = {Effect of l-stepholidine on rotational behavior in rats},
journal = {Acta Pharmacologica Sinica},
volume = {5},
number = {4},
year = {2016},
keywords = {},
abstract = {l-Stepholidine(SPD)is an analog of l-tetrahydropalmatine(THP) and tetrahydroberberine (THB). The effect of SPD on central dopaminergic system was studied in rats with unilateral nigral lesion induced by microinjection of 6-OHDA or electrocoagulation.
Results: 1) SPD produced contralateral circlings in both lesioned models of rats; 2) In chemical lesioned rats, SPD potentiated apomorphine-induced contralateral rotation, but reversed amphetamine-induced ipsiateral rotation; 3) In electrolytic lesioned rats, both apomorphine- and amphetamine-induced ipsilateral rotation were reversed by SPD.
The evidences indicate that SPD is an antagonist of DA receptor with some agonistic effects, and in particular, it is a new chemical type of dopaminergic active agent.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4755}
}