TY - JOUR AU - Song Jie-yun AU - He Xiu-ze AU - Chen Xiu-fen AU - Hu Ju-ying AU - Luo Gui-ying AU - Mo Yan-zhu PY - 2016 TI - Hypotensive effect of nevadensin JF - Acta Pharmacologica Sinica; Vol 6, No 2 (June 1985): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - In anesthetized dogs and cats, iv,im or intraduodenal injection of nevadensin 2-40 mg/kg lowered the BP 64±7 mmHg, but the heart rate and respiration remained unchanged. The BP gradually returned to its original level in 2-4 h. In dogs the BP was lowered more by nevadensin (2 mg/kg) than by reserpine(1.5 mg/kg) or hexamethonium.The hypotensive effect of nevadensin and total alkaloids of Rauwolfia were similar. The mechanism of its hypotensive action appears to be both central and peripheral in nature. UR - http://www.chinaphar.com/article/view/4745