@article{APS4740,
author = {Ji-zou Xiang and Ba Scholkens and W Linz and T Unger and D Ganten and Re Lang},
title = {Comparisons of effects of Hoe-498 and enalapril in isolated guinea pig hearts and rat myocardium},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {2},
year = {2016},
keywords = {},
abstract = {In isolated guinea pig hearts Hoe-498 (1 mg/kg ig) attenuated the cardiac effects of angiotensin I (ANG I) but not angiotensin II(ANG II), and potentiated those of brady-kinin(BK). Enalapril (MK-421) was without effect at this dose, but 30 mg/kg produced similar effects. In rat myocardium, the converting enzyme (CE) activities after Hoe-498 (1 mg/kg ig) pretreatment (15 min,1&6 h) were inhibited by 62.70 and 19%, repectively. Enalapril (30 mg/kg ig) pretreatment yielded similar inhibitions(74,76 and 50%,respectively). The results indicate that Hoe-498 is 30 times more potent as a CE inhibitor(CEI) than enalapril.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4740}
}