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Effect of soman on the medullary cardiovascular center of the cat and its relation to cholinergic receptors

   
@article{APS4734,
	author = {Xia-ping Xie and Chuan-gui Liu},
	title = {Effect of soman on the medullary cardiovascular center of the cat and its relation to cholinergic receptors},
	journal = {Acta Pharmacologica Sinica},
	volume = {6},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Injection of M-cholinergic agonist arecoline 5 microg, N-cholinergic agonist nicotine 7.5 mcirog or cholinesterase inhibitor soman 2 microg into the vertebral artery of the urethan-anesthetized cat elicited a simultaneous decrease of sympathetic efferent discharges of splanchic nerve and blood pressure. Nicotine and soman produced additional bradycardia which disappeared after bilateral cervical vagotomy.After blocking M-cholinergic receptors by pretreatment with M-cholinergic antagonist QNB 20 microg via vertebral artery, the effect of soman on medullary cardiovascular center showed a N-like action characterized by marked hypotension and bradycardia with a marked tendency to spontaneous recovery in a few minutes; while after blocking N-cholinergica receptors by N-cholinergic antagonist mecamylamine 150 microg, the effect of soman showed a M-like action characterized by prolonged hypotension without bradycardia.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4734}
}