@article{APS4708,
author = {Xiao Zhang and Bo-yi Qin},
title = {Relationship between cholinesterase activity and acetylcholine of the brains of mice acutely intoxicated with soman},
journal = {Acta Pharmacologica Sinica},
volume = {6},
number = {1},
year = {2016},
keywords = {},
abstract = {In mice following soman 100 microg/kg sc intoxication the dynamic courses of recovery of the toxic signs and the Ach content of brain tissue showed a parallelism. After soman q 12 h sc for 4 and 5 times with above dose,the ChE activity of mouse brain was once equal to 0% of normal as measured by hydroxylamine spectrophotometry, whereas it was found to be repectively 2.5 and 1.2% of normal measured by radiochemistry assay. Having incubated at 37 ºC for 20 min, the residual ChE almost completely hydrolyzed the [3H] Ach which was added at 49 micromol/mL. More recovery of the enzyme was found in the reserve ChE than that in the fuctional ChE.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4708}
}