@article{APS4696,
author = {Gang Cheng and Geng Xu and Hong-wen Cai and Hui-hua Wang and Xiao-feng Bao},
title = {Effect of atorvastatin on non-ischemic heart failure and matrix metalloproteinase-2 and 9 in rats},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {4},
year = {2016},
keywords = {},
abstract = {Aim: To examine the role of atorvastatin on volume-overload-induced heart failure and to test the hypothesis that atorvastatin inhibits MMP-2 and 9 expression in heart failure with non-ischemic etiology.
Methods: Arteriovenous (AV) fistulatreated rats were administered with atorvastatin (3 mg·kg-1·d-1) or vehicle for 17 weeks. Ventricular hypertrophy and heart failure were assessed by echocardiography, B-type natriuretic peptide BNP mRNA level and morphological measurement. MMP-2, 9 expression were measured by Western blot and zymography.
Results: Atorvastatin decreased left ventricular end diastolic diameter from 6.86±0.51 mm to 6.28±0.37 mm (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4696}
}