@article{APS4683,
author = {Hui-juan Ma and Ya-kun Cao and Yi-xian Liu and Ru Wang and Yu-ming Wu},
title = {Microinjection of resveratrol into rostral ventrolateral medulla decreases sympathetic vasomotor tone through nitric oxide and intracellular Ca 2+ in anesthetized male rats},
journal = {Acta Pharmacologica Sinica},
volume = {29},
number = {8},
year = {2016},
keywords = {},
abstract = {Aim: To define the effect of resveratrol (RES) on the central regulation of blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA).
Methods: RES was microinjected into the rostral ventrolateral medulla (RVLM), and BP, HR, and RSNA were recorded simultaneously in anesthetized rats.
Results: A microinjection of RES (20, 40, and 80 μmol/L, 0.2 μL) into the RVLM dose dependently decreased BP, HR and RSNA. Pretreatment with an anti-estrogen tamoxifen (100 μmol/L, 0.2 μL) did not affect the effects of RES. Pretreatment with NG-nitro-L-arginine methyl ester (100 μmol/L, 0.2 μL), an inhibitor of nitric oxide (NO) synthase, could completely abolish the effect of RES. A prior microinjection of Bay K8644 (500 nmol/L, 0.2 μL), an agonist of calcium channels, could also abrogate the effect of RES. Prior administration of a potent inhibitor of tyrosine phosphatase, sodium orthovanadate (1 mmol/L, 0.2 μL), could partially attenuate the inhibitory effect of RES.
Conclusion: The results suggest that a microinjection of RES into the RVLM inhibits BP, HR, and RSNA. The effects may be mediated by NO synthesis and a decrease in Ca2+ influx, in which protein tyrosine kinase is involved.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4683}
}