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l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons

   
@article{APS4653,
	author = {Ming Gao and Chang-liang Liu and Shen Yang and Xue-chu Zhen and Guo-zhang Jin},
	title = {l-Stepholidine increases the frequency of sEPSC via the activation of D 1  dopamine signaling pathway in rat prelimbic cortical neurons},
	journal = {Acta Pharmacologica Sinica},
	volume = {28},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the effect of l-stepholidine (SPD) on the frequency of spontaneous excitatory postsynaptic currents (sEPSC) in the pyramidal cells between layers V and VI in the prelimbic cortex (PL).
Methods: A whole-cell patch clamp in rat brain slices was used.
Results: SPD significantly increased the frequency of sEPSC in a concentration-dependent manner. A selective D1 dopamine receptor antagonist SCH23390 blocked SPD-mediated effects, whereas the D1agonist SKF38393, but not the D2/3 antagonist sulpiride, mimicked SPD-mediated increase in the frequency of sEPSC. Moreover, both protein kinase A (PKA) inhibitor N-(2-[p-bromocinnamylamino]-ethyl)-5-isoquinolinesulfonamide hydrochloride and protein kinase C (PKC) inhibitor chelerythrine attenuated the effect of SPD on sEPSC.
Conclusion: SPD elicits its effect on the frequency of sEPSC on the PL pyramidal cells via presynaptic D1 receptors, and is dependent on PKA and PKC signaling pathways.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4653}
}