TY - JOUR AU - Huang Hou-pin AU - Cheng Cai-fen AU - Lin Wen-qin AU - Yang Guo-xiong AU - Song Jie-yun AU - Ren Guang-you PY - 2016 TI - Antitumor activity of total saponins from Dolichos falcatus Klein JF - Acta Pharmacologica Sinica; Vol 3, No 4 (December 1982): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The total saponins, isolated from the root of Dolichos falcatus Klein, ip to mice showed a marked antitumor activity on sarcoma 37 but no effects on sarcoma 180, U14, Ehrlich ascites carcinoma and Ehrlich solid carcinoma. The saponins caused a direct lethal cytotoxicity on S37, but had no effect on phagocytic index of peritoneal phagocytes in the mice. The acute ig and ip LD in mice were 510±40 and 14.9±1.4 mg/kg, respectively. When the saponins were injected sc 10 mg/kg qd×14 d, no noticeable changes were seen in blood picture, urine routine test and morphology of heart, liver, spleen, lungs and kidneys. UR - http://www.chinaphar.com/article/view/4640