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Antitumor activity of total saponins from Dolichos falcatus Klein

   
@article{APS4640,
	author = {Hou-pin Huang and Cai-fen Cheng and Wen-qin Lin and Guo-xiong Yang and Jie-yun Song and Guang-you Ren},
	title = {Antitumor activity of total saponins from Dolichos falcatus Klein},
	journal = {Acta Pharmacologica Sinica},
	volume = {3},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The total saponins, isolated from the root of Dolichos falcatus Klein, ip to mice showed a marked antitumor activity on sarcoma 37 but no effects on sarcoma 180, U14, Ehrlich ascites carcinoma and Ehrlich solid carcinoma. The saponins caused a direct lethal cytotoxicity on S37, but had no effect on phagocytic index of peritoneal phagocytes in the mice. 
  The acute ig and ip LD in mice were 510±40 and 14.9±1.4 mg/kg, respectively. When the saponins were injected sc 10 mg/kg qd×14 d, no noticeable changes were seen in blood picture, urine routine test and morphology of heart, liver, spleen, lungs and kidneys.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4640}
}