%0 Journal Article %T Histochemical studies on the effect of furapyrimidone on Litomosoides carinii in cotton rats %A Yang Yuan-qing %A Yang Hui-zhong %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Histochemical studies on the effect of furapyrimidone on Litomosoides carinii in cotton rats %K %X Cotton rats infected with were treated intragastrically with furapyrimidone 15 mg/kg/d×7 d. The histochemical changes of the worms were observed. The contents of glycogen, RNA, DNA, alkaline protein, protein-boundα-amino groups, protein-bound tyrosine, tryptophan, histidine, SH groups, phenol substance, the activities of ATPase and AKP in the filariae or microfilariae showed a decrease 3 d after the initiation of treatment. Some of them were markedly decreased or even disappeared 7 d after the initiation of treatment. On the contrary, the activity of ACP was higher than that in the control. There was no recovery even 7 d after the completion of the treatment. %U http://www.chinaphar.com/article/view/4632 %V 3 %N 4 %P 276-279 %@ 1745-7254