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Toxicity and repository antimalarial activity of octanoyl primaquine

	author = {Song Zhang and Wen-zhuang Yao and Ling Su and Jun Zhang},
	title = {Toxicity and repository antimalarial activity of octanoyl primaquine},
	journal = {Acta Pharmacologica Sinica},
	volume = {3},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Octanoyl primaquine, a new compound synthesized in our College, was dissolved in castor oil and tea seed oil (3: 2). In mice, a single sc of 400 mg/kg almost completely prevented or suppressed patent infections of trophozoite-inducedup to 3—4 wks (Table 1). In antirelapse experiments against secondary tissue schizonts in rhesus monkeys, im 10 mg/kg showed an appreciable activity against tissue stage (Table 2). The acute sc LDin mice=798±28 mg/kg. In dogs, im 60 mg/kg, not 30 mg/kg, caused intestinal bleedings in one of the 5 dogs, and a slight hyperemia of injected muscle tissue was found at the im sites in 5 d. No discernible gross reactions were observed at 72, 120 and 168 h after im in rabbits. All of the 16 monkeys tolerated the dose of 5—20 mg/kg well.},
	issn = {1745-7254},	url = {}