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Analgesic and antipyretic effects of trilobine hydrochloride without induction of physical dependence

   
@article{APS4620,
	author = {Lin-zhong ZHENG and Jian-quan TAN and Xi-can TANG},
	title = {Analgesic and antipyretic effects of trilobine hydrochloride without induction of physical dependence},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Trilobine-HCI raised the pain thresholds during hot-plate test in mice, tail flick test in rats and writhing test in mice. Daily ip of 30 mg/kg×5 d in mice did not induce tolerance as seen with morphine. After in for 7 times within 2 d at 2.5 to 35 mg/kg in mice and then challenged with nalorphine 50 mg/kg, no jumping response was seen. In morphine-addicted rats the body weight was restored after sc morphine but not after trilobine. In morphine-addicted monkeys sc trilobine could not substitute morphine for releving the withdrawal syndromes.   The results demonstrate that trilobine acts as an analgesic drug, shows no morphine-like tolerance nor physical dependence. Hence it belongs to the non-narcotic group.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4620}
}