TY - JOUR AU - Chu Yun-hong AU - Zhou Mei-hua AU - Li Quan AU - Zhao Zi-fang PY - 2016 TI - Action of 15-methyl-prostaglandin F2 alpha on progesterone receptors and estradiol receptors in rabbit uterus JF - Acta Pharmacologica Sinica; Vol 3, No 4 (December 1982): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - 15-Methyl-PGFiv to pseudopregnant and immature rabbits increased the amount of progesterone receptors (P-R) in uteri. The increase of P-R in pseudopregnant uteri was more marked than that in immature uteri. But no striking change of estradiol receptors and of Ka of both receptors was observed. Injection of 15-methyl-PGFto pseudopregnant rabbits decreased the plasma progesterone level, but did not enhance the spontaneous contraction of uteri. It is suggested that 1) The mechanism of the increase of P-R in uterus is mediated mainly through the luteolytic action of 15-methyl-PGF; 2) The P-R in uterus plays a role in regluation of uterine contraction. UR - http://www.chinaphar.com/article/view/4616