@article{APS4615,
author = {Yuan-yan Zhou and Hong-yong Wang},
title = {Auto- and hetero-antagonistic actions of drugs},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {4},
year = {2016},
keywords = {},
abstract = {Auto-antagonism (AA) means that a drug antagonizes its own action and hetero-antagonism (HA) means that drugs with similar action antagonize each other.
The AA and HA actions between 7 drugs (ACh, PGE, 5-HT, A, NA, PE and DA) were studied and new methods for deterininations of AA and HA doses were developed.
1. All of these 7 drugs exhibited AA and HA actions, but their durations were rather short. These actions occurred when the drug evoked the muscle contraction and weakened or disappeared when the muscle relaxed.
2. The magnitude of AA dose varied with that of the control dose, but the ratio of AA dose to control dose often fell within the range of 8—32.
3. For drugs acting on the same receptor, their AA doses were almost always equal to their HA doses. The ratio of HA dose to AA dose was approximately equal to 1.
4. For drugs acting on different receptors, their AA dose and HA dose differed a great deal. The ratio between HA dose and AA dose may be either >1 or },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4615}
}