TY - JOUR AU - Chen En-hong AU - Tu Zeng-hong AU - Yang Hui-hua AU - Wu Wei-wei PY - 2016 TI - Effects of changrolin and pyracrine phosphate on ATPase of rabbit heart sarcolemma JF - Acta Pharmacologica Sinica; Vol 3, No 3 (September 1982): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Changrolin, 4-{3’,5’-bis [(N-pyrrolidinyl) methyl]-4’-hydroxy-anilino} quinazoline, was synthesized in our institute for treatment of arrhythmia. When the quinazoline ring of changrolin was substituted by an acridine ring, the compound was named pyracrine phosphate. The rabbit heart sarcolemma was prepared according to the method of McNa-mara(5), except that the left ventricle was homogenized by a glass homogenizer and, in the last step, the membrane was extracted with 2 M LiBr. The inhibitory effects of changrolin and quinidine (1 mM) on the Na+, K+-ATPase activity were 24% and 50%, respectively. The inhibitory effects of pyracrine phosphate and mepacrine on Na+, K+-ATPase were more potent. The inhibitory effect of pyracrine phosphate was similar to that of ouabain. The effects of changrolin and pyracrine phosphate on Ca2+-ATPase activity were not significant at 0.5 and 1 mM. UR - http://www.chinaphar.com/article/view/4582