TY - JOUR AU - Chen Yi-yue AU - Fang Da-chao AU - Lu Fu-hua PY - 2016 TI - Effects of tetrandrine on inotropic and toxic actions of cardiac glycosides and its relation to extracellular calcium JF - Acta Pharmacologica Sinica; Vol 3, No 3 (September 1982): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The effects of tetrandrine (T) or Ca2+ on inotropic and toxic actions of 2 cardiac glycoside preparations, divasid and ouabain, were studied with isolated left atria of rabbits. Tetrandrine at a low but still hypotensive effective concentration (4.8μM) prolonged PET and reduced the toxicity of the 2 preparations. No effect on the degree of contraction amplitude increment was observed. These effects of tetrandrine are not attributable to its negative inotropic action. Since they were antagonized by Ca2+, it may be assumed that tetrandrine is a calcium antagonist. UR - http://www.chinaphar.com/article/view/4580