@article{APS4572,
author = {Wan-ying Mo and Yue-iang Chou and Gen-nian Wang},
title = {Analgesia by injection of morphine and antagonism of electro-acupuncture analgesia by injection of naloxone into septal area of rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {3},
year = {2016},
keywords = {},
abstract = {The present work was carried out to investigate the role of the septal area in morphine and acupuncture analgesia in rabbits. Electrophoresis of K+ into the skin of rabbit's ear serving as the noxious stimulus and the minimal electric current required to produce the defense motor response of the head and forelimbs were taken as pain threshold.
Twenty-one min after bilateral microinjections of morphine (40μg / 2μl) through chronically implanted cannulae into the septal area, the pain threshold increased markdly and lasted more than 2 h. The rate of increase was 65±(SD)12% within 21-60 min and it revealed a significant difference as compared with the control values (10 rabbits). No noticeable change was found in the control experiments (10 rabbits).
Fifteen min after bilateral injections of etorphine (4μg/2μl) into the septal area, the pain threshold increased strikingly in 15-51 min (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4572}
}