TY - JOUR AU - Hu Yu–lin AU - Xie Yu-yuan AU - Tao Zheng-qin AU - Chen Zhen-jia AU - Zhang Jian-shi AU - Ding Guang-sheng AU - Ye De-hua AU - Wang Yun AU - Ma Ji-xiao PY - 2016 TI - Bleomycin A derivative, 99mTc-BLAIDA: synthesis and distribution in tumor-bearing mice (author's transl) JF - Acta Pharmacologica Sinica; Vol 3, No 2 (June 1982): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - N-(4-bromoacetylaminoace-tanilido) iminodiacetic acid (AIDA) was synthesized by condensation of p-nitroaniline with nitrilotriacetic acid, catalytic reduction and subsequent acylation with bromoacetyl bromide. AIDA was conjugated with cobalt-bleomycin A5 to give BLAIDA, which was in turn labeled with 99mTc to yield 99mTc-BLAIDA. 99mTc-BLAIDA was tested on mice bearing sarcoma 180, brain tumor-22, murine hepatoma or Lewis lung carcinoma. The radioactivities in tumors were much higher than those in blood and other organs. The tumor/organ ratio was highest in case of sarcoma 180 at 12 h after iv 99mTc—BLAIDA. Hence 99mTc-BLAIDA is a potential tumor localizing agent for clinical diagnosis. UR - http://www.chinaphar.com/article/view/4556