@article{APS4554,
author = {Bin-yao Wang and Guo-rui Yu and Dao-sheng Zheng and Ming-xin Huang and Bei-kun Gu and Yian-lian Chen and Ming Shang and Zheng-jun Jin},
title = {Effects of dl-demethylcoclaurine on electrophysiological properties of porcine myocardial cells (author's transl)},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {2},
year = {2016},
keywords = {},
abstract = {Action potentials of isolated ventricular myocardial fibers of pigs and the electrophysiological actions of dl-demethylcoclaurine (DMC) on the porcine myocardial cells were studied by glass microeletrodes.
The action potentials of porcine ventricular myocardial fibers were similar to those of other mammalian hearts. Amplitude of the action potential was 115±9 mV, duration of action potential 242±30 ms, resting membrane potential -85±5 mV and the maximum rise of depolarization of action potential 151±27 V/s.
After perfusion with normal Tyrode’s solution containing DMC 5 μg/ml,the amplitude of action potential was increased and the duration of action potential was prolonged, the amplitude and the duration of plateau of action potential were increased and the slope of phase 2 of action potential was reduced (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4554}
}