@article{APS4497,
author = {Zu-wu Wang and Rong-sheng Shu and Bin Xu},
title = {Nucleolus segregation of tumor cells induced by actinomycin K and lycobetaine},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {1},
year = {2016},
keywords = {},
abstract = {Actinomycin K significantly induced nucleolus segregation (NuS), mainly macrosegregation of both hepatoma cells and liver cells in mice. The peak of NuS was 19.6±(SD) 1.4% in hepatoma cells 4 h after ip 400 μg/kg and 13.6±1.3 % in liver cells 8 h after ip. In the segregated Nu the volume of fibrous portion was twice as that of granular portion. They were 0.67±0.06 μm3/μm3 Nu and 0.28±0.08 μm3/μm3 Nu, respectively. Vincristine, 10- hydroxycamptothecin and mitomycin inhibited the NuS induced by actinomycin K. Lycobetaine 40 mg/kg could also induce NuS in Ehrlich ascitic carcinoma, mainly microsegregation 4 h after ip.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4497}
}