TY - JOUR AU - Xiao Ying AU - Xue Xiang AU - Wu Yuan-feng AU - Xin Guo-zheng AU - Qian Yong AU - Xie Tian-pei AU - Gong Li-kun AU - Ren Jin PY - 2016 TI - β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism JF - Acta Pharmacologica Sinica; Vol 30, No 11 (November 2009): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: The role of CYP1A in the protection of aristolochic acid (AA)I-induced nephrotoxicity has been suggested. In the present study we investigated the effects of β-naphthoflavone (BNF), a non-carcinogen CYP1A inducer, on AAI-induced kidney injury. Methods: Mice were pretreated with 80 mg/kg BNF by daily intraperitoneal injection (ip) for 3 days followed by a single ip of 10 mg/kg AAI. AAI and its major metabolites in blood, liver and kidney, the expression of CYP1A1 and CYP1A2 in microsomes of liver and kidney, as well as the nephrotoxicity were evaluated. Results: BNF pretreatment prevented AAI-induced renal damage by facilitating the disposal of AAI in liver. BNF pretreatment induced the expression of CYP1A1 in both liver and kidney; but the induction of CYP1A2 was only observed in liver. Conclusion: BNF prevents AAI-induced kidney toxicity primarily through CYP1A induction. UR - http://www.chinaphar.com/article/view/4430