%0 Journal Article %T β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism %A Xiao Ying %A Xue Xiang %A Wu Yuan-feng %A Xin Guo-zheng %A Qian Yong %A Xie Tian-pei %A Gong Li-kun %A Ren Jin %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism %K %X Aim: The role of CYP1A in the protection of aristolochic acid (AA)I-induced nephrotoxicity has been suggested. In the present study we investigated the effects of β-naphthoflavone (BNF), a non-carcinogen CYP1A inducer, on AAI-induced kidney injury. Methods: Mice were pretreated with 80 mg/kg BNF by daily intraperitoneal injection (ip) for 3 days followed by a single ip of 10 mg/kg AAI. AAI and its major metabolites in blood, liver and kidney, the expression of CYP1A1 and CYP1A2 in microsomes of liver and kidney, as well as the nephrotoxicity were evaluated. Results: BNF pretreatment prevented AAI-induced renal damage by facilitating the disposal of AAI in liver. BNF pretreatment induced the expression of CYP1A1 in both liver and kidney; but the induction of CYP1A2 was only observed in liver. Conclusion: BNF prevents AAI-induced kidney toxicity primarily through CYP1A induction. %U http://www.chinaphar.com/article/view/4430 %V 30 %N 11 %P 1559-1565 %@ 1745-7254