@article{APS4291,
author = {Wei-li Liu and Shu-jie Chen and Yan Chen and Lei-min Sun and Wei Zhang and Ya-min Zeng and Tian-hua Zhou and Jian-min Si},
title = {Protective effects of heat shock protein70 induced by geranyl- geranylacetone in atrophic gastritis in rats},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {7},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the effect of geranylgeranylacetone (GGA) on the progression of atrophic gastritis in rats and its potential mechanism.
Methods: Atrophic gastritis was induced in Sprague-Dawley rats with 0.1% ammonia solution, 60% ethanol, and 20 mmol/L deoxycholic acid for 24 weeks. Accompanied by the induction of atrophic gastritis, 200 mg/kg GGA was administered by oral gavage for 8 weeks (weeks 17-24). The histological changes in gastric mucosa were quantitated by the index of inflammation, the gastric mucosal thickness, and the amount of glands of 1 mm horizontal length in antrum. Endogenous heat shock protein (HSP)70 levels and distribution were determined by immunoblotting and immunohistochemistry in gastric mucosa.
Results: GGA alleviated the pathological progression of atrophic gastritis with inflammation relief (inflammation index: 1.40 in the GGA group and 1.65 in the atrophic gastritis group) and glandular restoration (mucosal thickness and quantity of glands: 194.3 μm and 38.7 mm in the GGA group; 123.3 μm and 32.7 mm in the atrophic gastritis group; P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4291}
}