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Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway

   
@article{APS4276,
	author = {Yang Xue and Ying Wang and De-chun Feng and Bao-guo Xiao and Ling-yun Xu},
	title = {Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway},
	journal = {Acta Pharmacologica Sinica},
	volume = {29},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Aim: Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine (TET), a major pharmacologically-active compound of Chinese herb Stephania tetrandra S Moore on microglial activation. 
Methods: The microglia pretreated with or without TET were activated by lipopolysaccharide (LPS) in vitro. Nitric oxide (NO) release, superoxide anion (O2–) generation, as well as TNF-α and interleukin-6 (IL-6) production by microglia were measured afterwards. Electrophoretic mobility shift assay was performed to determine whether NF-κB activity in microglia was affected by TET treatment. 
Results: We found that TET inhibited the LPS-induced activation of microglia by decreasing the production of NO and O2–, consequently affecting the release of TNF-α and IL-6 in LPS-induced microglial activation. Such suppressive effect was accompanied by inhibiting transcription factor NF-κB activation.
Conclusion: Our results suggest that TET might modulate LPS-induced microglial activation by inhibiting the NF-κB-mediated release of inflammatory factors.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4276}
}