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Differentiation between catalepsies induced by l-tetrahydropalmatine and by haloperidol and morphine

   
@article{APS4168,
	author = {Jian Xu and Guo-zhang Jin and Lei-ping Yu and Xue-jun Liu},
	title = {Differentiation between catalepsies induced by l-tetrahydropalmatine and by haloperidol and morphine},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {By means of gel-permeable chromatography with Sephadex G-10 the brain DA and momovanillic acid (HVA) were isolated and then determined fluorospectrometrically. After ip l-tetrahydropalmatine (l-THP) 100 mg/kg in rats or iv 40 mg/kg in rabbits the HVA level in nucleus caudatus was elevated significantly. Thus, l-THP stimulated the activities of nucleus caudatus DA neurons.
Rats wereused in catalepsy experiment. l-THP (70 or 100 mg/kg, ip), morphine (20 or 30 mg/kg, ip) or haloperidol (0.13-1.0 mg/kg, ip) could, but d-THP (200 mg/kg, ip) could not induce catalepsies. Haloperidol-induced catalepsy could be antagonized selectively by ip scopolamine 5 mg/kg, and morphine-induced catalepsy by ip naloxone 1 mg/kg. On the other hand, l-THP-induced catalepsy was potentiated by ip aminoxyacetic acid (AOAA 10 mg/kg) which is well-known as an inhibitor of GABA-transaminase. Therefore, we deduce that the l-THP-induced catalepsy may be related with GABA-ergic system},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4168}
}