@article{APS4143,
author = {Jin-chuan Yan and Shu Ding and Yi Liang and Gen-shan Ma and Jian Zhu and Yi Feng and Dan Luo},
title = {Relationship between upregulation of CD40 system and restenosis in patients after percutaneous coronary intervention},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {3},
year = {2016},
keywords = {},
abstract = {Aim: To investigate whether the increasing CD40-CD40 ligand system is related to restenosis in patients after percutaneous coronary intervention (PCI). Methods: Twenty normal controls and 120 patients with PCI were investigated. The expression of CD40 and the CD40 ligand (CD40L) on platelets was analyzed by indirect-immunofluorescence flow cytometry. The serum level of soluble CD40L (sCD40L) and C-reactive protein (CRP) was determined by commercially available enzyme linked immunosorbent assay. Restenosis was observed in 120 patients within a 6 month follow-up period after PCI surgery. Results: Restenosis occurred in 29 patients (24.2%). Patients who developed restenosis showed higher levels of CD40-CD40L system compared with non-restenotic patients before PCI. All restenotic patients showed a significant increase in CD40 [66.9 4.8, mean fluorescence intensity (MFI)] and CD40L (14.9 1.8, MFI) co-expression on platelets as well as sCD40L (13.7 1.7 ng/mL) compared with non-restenotic patients and controls during the 6 month follow-up period (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4143}
}