TY - JOUR AU - Wang Cheng AU - You Zi-li AU - Xia Qing AU - Xiong Tao AU - Xia Yang AU - Yao De-zhong PY - 2016 TI - Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus JF - Acta Pharmacologica Sinica; Vol 28, No 3 (March 2007): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus. Methods: The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus. Results: JuA significantly decreased the total activity intensity ( P vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein 1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus. Conclusion: JuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus. UR - http://www.chinaphar.com/article/view/4142