%0 Journal Article %T Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus %A Wang Cheng %A You Zi-li %A Xia Qing %A Xiong Tao %A Xia Yang %A Yao De-zhong %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus %K %X Aim: To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus. Methods: The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus. Results: JuA significantly decreased the total activity intensity ( P vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein 1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus. Conclusion: JuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus. %U http://www.chinaphar.com/article/view/4142 %V 28 %N 3 %P 334–338 %@ 1745-7254