@article{APS4126,
author = {Hui-wan Han and Jia-zhen Wang and Fu-li Sun and Gui-yun Zeng},
title = {Effect of dl-demethylcoclaurine on cultured rat heart cells},
journal = {Acta Pharmacologica Sinica},
volume = {2},
number = {2},
year = {2016},
keywords = {},
abstract = {Cells from newborn rat hearts were cultured in Eagle MEM. Chronotropican inotropic responses of the cells to dl-demethylcoclaurine (DMG) were recorded photoelectrically.
The rate of contractions of the cells increased significantly when DMG was added. At the final concentration of 10(-6), 10(-5), 10(-4), and 10(-3) M, the beating rate increased by 19, 32, 26, and 18%, respectively. At 10(-5) and 10(-4) M the amplitudes of beats of the contractions of some cell clusters, but decreased in others.
Both the rate and amplitude of contractions were augmented significantly in 10(-6) M isoprenaline (ISO). The positive chronotropic and inotropic responses to ISO were greater than those elicited by DMC.
Anti-arrhythmic effect was seen in ISO 10(-6) M or DMC 10(-5)-10(-4) M.
The effects of both ISO 10(-6) M and DMC 10(-5) M were antagonized by pindolol (PIN) 10(-6)-10(-5) M. However, PIN per se did not alter the beating rate. The results indicate that DMC activate the beta adrenoreceptors of rat heart cells.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4126}
}