%0 Journal Article %T Anti-arrhythmic and beta-adrenoceptor blocking activities of vanilol %A Pan Xin-xin %A Xiao Ji-gao %A Lu You-zhen %A Liu Tian-pei %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Anti-arrhythmic and beta-adrenoceptor blocking activities of vanilol %K %X Vanilol (1-(2-methoxy-4-methyoxycarbonyl-1-phenoxy)-3-isopropylamino-2-propanol) is a derivative of protocatechuic acid with the same side chain as that of propranolol. In the isolated rabbit left atria, the effective refractory period (ERP) could be prolonged by 16% y vanilol 10(-5) M. The aconitine-induced arrhythmia in rats and ouabain-induced arrhythmia in guinea pigs could be antagonized by the constant iv cumulative dose of vanilol 30 mg/kg. The epinephrine-induced arrhythmia in anesthetized dogs and rabbits could be prevented by iv vanilol 2 and 10 mg/kg, respectively. In anesthetized cats, the beta-adrenergic blocking potency of propranolol was approximately 73 times that of vanilol. The acute LD50 (+/-SD) in mice given by po, ip and iv were 401+/-102, 207+/-53 and 50+/-13 mg/kg, respectively. In subacute toxicity test in rats, vanilol was ip at daily doses of 50 and 100 mg/kg for 14 days. No noticeable changes of the blood picture, SGPT, morphology of liver and kidneys were observed. %U http://www.chinaphar.com/article/view/4123 %V 2 %N 2 %P 97-101 %@ 1745-7254