%0 Journal Article %T The blocking action of anabasin on the neuromuscular junction %A Yang Qin-zhao %A Shu Huai-de %A Lin Le-ru %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! The blocking action of anabasin on the neuromuscular junction %K %X Anabsin, an alkaloid extracted from the root of Alangium chinense, exerted a significant neuromuscular blocking effect on isolated rat phrenic nerve-diaphragm preparations. This blocking action could be partly antagonized by neostigmine. On rat denervated diaphragms, anabasin inhibited the muscular response to acetylcholine. Anabasin showed a depolarizing effect on isolated frog sartorius muscles. Anabasin (0.83 microg/ml) increased at first, and then decreased, the frequency of the miniature end-plate potentials (mepp). Anabasin inhibited the end-plate potential (epp) and its quantal content, but did not alter the nerve terminal potential (ntp). In conclusion, anabasin has both presynaptic and postsynaptic effects on neuromuscular junction. It is a depolarizing muscle relaxant with some characteristics of competitive muscle relaxant. %U http://www.chinaphar.com/article/view/4119 %V 2 %N 2 %P 84-88 %@ 1745-7254